A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation.

Mathew, Geetha; Sharma, Arpeeta; Pickering, Raelene J; Rosado, Carlos J; Lemarie, Jeremie; Mudgal, Jayesh; Thambi, Magith; Sebastian, Sarine; Jandeleit-Dahm, Karin A; de Haan, Judy B; Unnikrishnan, Mazhuvancherry K

Mathew, Geetha; Sharma, Arpeeta; Pickering, Raelene J; Rosado, Carlos J; Lemarie, Jeremie; Mudgal, Jayesh; Thambi, Magith; Sebastian, Sarine; Jandeleit-Dahm, Karin A; de Haan, Judy B; Unnikrishnan, Mazhuvancherry K.

Affiliation

Mathew G; a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.
Sharma A; b Oxidative Stress Laboratory, Basic Science Domain , Baker Heart and Diabetes Institute , Melbourne , Australia.
Pickering RJ; c Department of Diabetes, the Alfred Centre , Monash University , Melbourne , Australia.
Rosado CJ; b Oxidative Stress Laboratory, Basic Science Domain , Baker Heart and Diabetes Institute , Melbourne , Australia.
Lemarie J; c Department of Diabetes, the Alfred Centre , Monash University , Melbourne , Australia.
Mudgal J; c Department of Diabetes, the Alfred Centre , Monash University , Melbourne , Australia.
Thambi M; b Oxidative Stress Laboratory, Basic Science Domain , Baker Heart and Diabetes Institute , Melbourne , Australia.
Sebastian S; a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.
Jandeleit-Dahm KA; a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.
de Haan JB; a Department of Pharmacology, Manipal College of Pharmaceutical Sciences , Manipal Academy of Higher Education , Manipal , India.
Unnikrishnan MK; b Oxidative Stress Laboratory, Basic Science Domain , Baker Heart and Diabetes Institute , Melbourne , Australia.

Free Radic Res ; 52(10): 1140-1157, 2018 Oct.

Article in En | MEDLINE | ID: mdl-30422019

Subject(s)

Antioxidants/metabolism; Indans/pharmacology; Inflammation/drug therapy; NF-E2-Related Factor 2/antagonists & inhibitors; Small Molecule Libraries/pharmacology; Animals; Benzothiazoles/antagonists & inhibitors; Benzothiazoles/metabolism; Biphenyl Compounds/antagonists & inhibitors; Biphenyl Compounds/metabolism; Carrageenan; Cell Survival/drug effects; Cells, Cultured; Edema/chemically induced; Edema/drug therapy; Indans/chemical synthesis; Indans/chemistry; Inflammation/metabolism; Lipopolysaccharides/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Macrophages/metabolism; Male; Mast Cells; Mice; Mice, Knockout; NF-E2-Related Factor 2/deficiency; NF-E2-Related Factor 2/metabolism; Picrates/antagonists & inhibitors; Picrates/metabolism; RAW 264.7 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/analysis; Reactive Oxygen Species/metabolism; Small Molecule Libraries/chemical synthesis; Small Molecule Libraries/chemistry; Sulfonic Acids/antagonists & inhibitors; Sulfonic Acids/metabolism

Key words

Anti-inflammatory; Nrf2; antioxidant; macrophages; nonulcerogenic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Small Molecule Libraries / Indans / Inflammation / Antioxidants Type of study: Prognostic_studies Language: En Journal: Free Radic Res Journal subject: BIOQUIMICA Year: 2018 Document type: Article Affiliation country: India Country of publication: United kingdom

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