Comparison of multi-wall carbon nanotube and nitrogen-doped multi-wall carbon nanotube effects on lung function and airway reactivity in rats.
Toxicol Appl Pharmacol
; 364: 153-163, 2019 02 01.
Article
in En
| MEDLINE
| ID: mdl-30423287
ABSTRACT
Incorporation of multi-wall carbon nanotubes (MWCNT) into materials has raised concerns about their potential hazards to manufacturing workers. In animal models, airway inflammation and lung fibrosis follow aspiration, instillation, and inhalation exposures to MWCNT. However, the effects of MWCNT on pulmonary function, airway reactivity and airway epithelium function following inhalation exposure has not been studied. We investigated whether inhaled MWCNT affects lung resistance (RL) and dynamic compliance (Cdyn), reactivity to inhaled methacholine (MCh), epithelial regulation of airway reactivity to MCh in vitro, and airway epithelial ion transport. Male rats were exposed by whole body inhalation for 6â¯h to air or aerosolized MWCNT (0.5, 1 or 5â¯mg/m3) for one or nine days. Eighteen h after 1 d exposure to 5â¯mg/m3 MWCNT, basal RL was increased and basal Cdyn was decreased; changes did not persist for 7 d. Reactivity to MCh (RL) was increased and Cdyn responses were decreased at 18â¯h, but not 7 d after exposure to 1 and 5â¯mg/m3 MWCNT. The effects of i.t.-instilled MWCNT and nitrogen-doped MWCNT (N-MWCNT) on pulmonary function and reactivity to MCh at doses comparable to deposition after inhalation of 5â¯mg/m3 at 1 d and 0.5, 1, and 5â¯mg/m3 MWCNT 9 d-exposures were compared. Both nanoparticles increased airway reactivity (RL); N-MWCNT did not affect Cdyn responses. Lung function and airway reactivity are altered following a single MWCNT inhalation and generally subside over time. Given i.t., MWCNT's and N-MWCNT's effects were comparable, but N-MWCNT evoke smaller changes in Cdyn responses.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bronchoconstriction
/
Bronchial Hyperreactivity
/
Nanotubes, Carbon
/
Lung
/
Nitrogen
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Toxicol Appl Pharmacol
Year:
2019
Document type:
Article
Affiliation country:
United States