Astrocyte-neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord.

Miyamoto, Keisuke; Ishikura, Kei-Ichiro; Kume, Kazuhiko; Ohsawa, Masahiro

Miyamoto, Keisuke; Ishikura, Kei-Ichiro; Kume, Kazuhiko; Ohsawa, Masahiro.

Affiliation

Miyamoto K; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Ishikura KI; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Kume K; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Ohsawa M; Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

Glia ; 67(1): 27-36, 2019 01.

Article in En | MEDLINE | ID: mdl-30430652

Subject(s)

Astrocytes/metabolism; Hyperalgesia/metabolism; Lactic Acid/metabolism; Neurons/metabolism; Nociception/physiology; Spinal Cord/metabolism; Animals; Astrocytes/drug effects; Hyperalgesia/chemically induced; Injections, Spinal; Lactic Acid/administration & dosage; Lactic Acid/toxicity; Male; Mice; Neurons/drug effects; Nociception/drug effects; Spinal Cord/drug effects

Key words

L-lactate; astrocyte; mechanical allodynia; neuropathic pain; spinal cord

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Astrocytes / Lactic Acid / Nociception / Hyperalgesia / Neurons Limits: Animals Language: En Journal: Glia Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: Japan Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google