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Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.
Zhou, Xiaobo; Qu, Yuan Qing; Zheng, Zhiyuan; Law, Betty Yuen Kwan; Mok, Simon Wing Fai; Jiang, Zhi-Hong; Wong, Vincent Kam Wai; Bai, Li-Ping.
Affiliation
  • Zhou X; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.
  • Qu YQ; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.
  • Zheng Z; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.
  • Law BYK; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.
  • Mok SWF; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau.
  • Jiang ZH; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau. Electronic address: zhjiang@must.edu.mo.
  • Wong VKW; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau. Electronic address: kawwong@must.edu.mo.
  • Bai LP; State Key Laboratory of Quality Research in Chinese Medicine, and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau. Electronic address: lpbai@must.edu.mo.
Bioorg Chem ; 83: 450-460, 2019 03.
Article in En | MEDLINE | ID: mdl-30448723
ABSTRACT
Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells and their autophagic activity in HeLa model cell. Among these newly synthesized compounds, carbamates 2a, 2b, carbonyl ester 3a and sulfonyl ester 4a exhibited potent cytotoxic effects on tested cancer cells with IC50 values ranged from 2.72 to 12.53 µM, which were more potent than that of dauricine (higher than 15.53 µM). The above four derivatives are validated to induce autophagy-dependent cell death in HeLa cancer cells. These findings offer us a promising source for generating novel autophagic enhancers for anti-cancer therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylisoquinolines / Tetrahydroisoquinolines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Affiliation country: Macao

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylisoquinolines / Tetrahydroisoquinolines / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Affiliation country: Macao