Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.
Bioorg Chem
; 83: 450-460, 2019 03.
Article
in En
| MEDLINE
| ID: mdl-30448723
ABSTRACT
Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells and their autophagic activity in HeLa model cell. Among these newly synthesized compounds, carbamates 2a, 2b, carbonyl ester 3a and sulfonyl ester 4a exhibited potent cytotoxic effects on tested cancer cells with IC50 values ranged from 2.72 to 12.53⯵M, which were more potent than that of dauricine (higher than 15.53⯵M). The above four derivatives are validated to induce autophagy-dependent cell death in HeLa cancer cells. These findings offer us a promising source for generating novel autophagic enhancers for anti-cancer therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzylisoquinolines
/
Tetrahydroisoquinolines
/
Antineoplastic Agents
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Bioorg Chem
Year:
2019
Document type:
Article
Affiliation country:
Macao