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Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota.
Teng, Yun; Ren, Yi; Sayed, Mohammed; Hu, Xin; Lei, Chao; Kumar, Anil; Hutchins, Elizabeth; Mu, Jingyao; Deng, Zhongbin; Luo, Chao; Sundaram, Kumaran; Sriwastva, Mukesh K; Zhang, Lifeng; Hsieh, Michael; Reiman, Rebecca; Haribabu, Bodduluri; Yan, Jun; Jala, Venkatakrishna Rao; Miller, Donald M; Van Keuren-Jensen, Kendall; Merchant, Michael L; McClain, Craig J; Park, Juw Won; Egilmez, Nejat K; Zhang, Huang-Ge.
Affiliation
  • Teng Y; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA. Electronic address: yun.teng@louisville.edu.
  • Ren Y; Department of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.
  • Sayed M; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
  • Hu X; Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Lei C; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Kumar A; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Hutchins E; Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
  • Mu J; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Deng Z; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Luo C; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Sundaram K; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Sriwastva MK; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Zhang L; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Hsieh M; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
  • Reiman R; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
  • Haribabu B; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Yan J; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Jala VR; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Miller DM; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Van Keuren-Jensen K; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA.
  • Merchant ML; Kidney Disease Program and Clinical Proteomics Center, University of Louisville, Louisville, KY, USA.
  • McClain CJ; Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA.
  • Park JW; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40202, USA; KBRIN Bioinformatics Core, University of Louisville, Louisville, KY 40202, USA.
  • Egilmez NK; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA.
  • Zhang HG; Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA. Electronic address: h0zhan17@louisville.edu.
Cell Host Microbe ; 24(5): 637-652.e8, 2018 11 14.
Article in En | MEDLINE | ID: mdl-30449315
ABSTRACT
The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plants / MicroRNAs / Exosome Multienzyme Ribonuclease Complex / Gastrointestinal Microbiome / Intestines Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Host Microbe Journal subject: MICROBIOLOGIA Year: 2018 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plants / MicroRNAs / Exosome Multienzyme Ribonuclease Complex / Gastrointestinal Microbiome / Intestines Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Host Microbe Journal subject: MICROBIOLOGIA Year: 2018 Document type: Article