Flu DRiPs in MHC Class I Immunosurveillance.

Wei, Jiajie; Yewdell, Jonathan W

Wei, Jiajie; Yewdell, Jonathan W.

Affiliation

Wei J; Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Yewdell JW; Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. jyewdell@nih.gov.

Virol Sin ; 34(2): 162-167, 2019 Apr.

Article in En | MEDLINE | ID: mdl-30456657

ABSTRACT

ABSTRACT

Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8+ T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.

Subject(s)

Antigens, Viral/immunology; Defective Viruses/immunology; Influenza A virus/immunology; Monitoring, Immunologic; Animals; Antigens, Viral/genetics; CD8-Positive T-Lymphocytes/immunology; Defective Viruses/genetics; Histocompatibility Antigens Class I/immunology; Humans; Influenza A virus/genetics; Influenza, Human/immunology; Influenza, Human/prevention & control; Mice; Peptides/genetics; Peptides/immunology

Key words

DRiP; Immune responses; Influenza A virus (IAV); MHC class I; MHC-restricted cytotoxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Monitoring, Immunologic / Defective Viruses / Antigens, Viral Limits: Animals / Humans Language: En Journal: Virol Sin Journal subject: VIROLOGIA Year: 2019 Document type: Article Affiliation country: United States

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