Factors affecting mortality in children requiring continuous renal replacement therapy in pediatric intensive care unit.
Adv Clin Exp Med
; 28(5): 615-623, 2019 May.
Article
in En
| MEDLINE
| ID: mdl-30462382
ABSTRACT
BACKGROUND:
Acute kidney injury (AKI) occurs in up to 30% of pediatric intensive care unit (PICU) patients and is associated with a high mortality rate.OBJECTIVES:
The objective of the study was to evaluate factors associated with the outcome and to identify the prognostic factors in children receiving continuous renal replacement therapy (CRRT). MATERIAL ANDMETHODS:
This was a retrospective, single-center study, including 46 patients.RESULTS:
Logistic regression analysis demonstrated significant effects on patient survival exerted by the percentage of fluid overload (FO%) (odds ratio (OR) 1.030; p = 0.044). In the group of patients with FO% < 25%, the mortality was 33.3%, and in the FO% ≥ 25% group, the mortality was 67.9% (p < 0.001). The probability of death without multi-organ failure (MOF) was 13%, while with MOF it was 74%. There was no difference in the duration of hospitalization between the CRRT patients (mean 21.9 days) and the general population of children hospitalized in PICU in the same period (n = 3,255; mean 25.4 days); however, a significant difference was noted in mortality between the 2 groups of patients (54% vs 6.5%; p < 0.001).CONCLUSIONS:
The mortality of PICU CRRT patients is more than 8-fold higher than the mortality of the total PICU population. Coexisting MOF increases the mortality almost 6 times. The mortality of children with FO% ≥ 25% was more than 2-fold higher than the mortality of children with FO% < 25%.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water-Electrolyte Imbalance
/
Intensive Care Units, Pediatric
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Renal Replacement Therapy
/
Acute Kidney Injury
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
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Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Adv Clin Exp Med
Year:
2019
Document type:
Article
Affiliation country:
Poland