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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Wood, Daniel J; Korolchuk, Svitlana; Tatum, Natalie J; Wang, Lan-Zhen; Endicott, Jane A; Noble, Martin E M; Martin, Mathew P.
Affiliation
  • Wood DJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Korolchuk S; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Tatum NJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Wang LZ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Endicott JA; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  • Noble MEM; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: martin.noble@ncl.ac.uk.
  • Martin MP; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: mathew.martin@ncl.ac.uk.
Cell Chem Biol ; 26(1): 121-130.e5, 2019 01 17.
Article in En | MEDLINE | ID: mdl-30472117
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CDC2 Protein Kinase / Entropy / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 2 Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CDC2 Protein Kinase / Entropy / Protein Kinase Inhibitors / Cyclin-Dependent Kinase 2 Limits: Humans Language: En Journal: Cell Chem Biol Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: United States