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Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
Takeuchi, Fumihiko; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohiro; Nakatochi, Masahiro; Tabara, Yasuharu; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; Spracklen, Cassandra N; Chai, Jin-Fang; Kim, Young-Jin; Zhang, Liang; Wang, Chaolong; Li, Huaixing; Li, Honglan; Wu, Jer-Yuarn; Dorajoo, Rajkumar; Nierenberg, Jovia L; Wang, Ya Xing; He, Jing; Bennett, Derrick A; Takahashi, Atsushi; Momozawa, Yukihide; Hirata, Makoto; Matsuda, Koichi; Rakugi, Hiromi; Nakashima, Eitaro; Isono, Masato; Shirota, Matsuyuki; Hozawa, Atsushi; Ichihara, Sahoko; Matsubara, Tatsuaki; Yamamoto, Ken; Kohara, Katsuhiko; Igase, Michiya; Han, Sohee; Gordon-Larsen, Penny; Huang, Wei; Lee, Nanette R; Adair, Linda S; Hwang, Mi Yeong; Lee, Juyoung; Chee, Miao Li; Sabanayagam, Charumathi; Zhao, Wanting; Liu, Jianjun; Reilly, Dermot F; Sun, Liang; Huo, Shaofeng.
Affiliation
  • Takeuchi F; Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
  • Akiyama M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
  • Matoba N; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Katsuya T; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Nakatochi M; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Tabara Y; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Narita A; Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, 466-8560, Japan.
  • Saw WY; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
  • Moon S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
  • Spracklen CN; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
  • Chai JF; Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
  • Kim YJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea.
  • Zhang L; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA.
  • Wang C; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
  • Li H; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea.
  • Li H; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
  • Wu JY; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
  • Dorajoo R; Duke-NUS Medical School, Singapore, 169857, Singapore.
  • Nierenberg JL; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Wang YX; CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
  • He J; State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
  • Bennett DA; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
  • Takahashi A; School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan.
  • Momozawa Y; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
  • Hirata M; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
  • Matsuda K; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
  • Rakugi H; Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN 37203-1738, USA.
  • Nakashima E; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Isono M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Shirota M; Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, 565-0873, Japan.
  • Hozawa A; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Ichihara S; Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
  • Matsubara T; Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8561, Japan.
  • Yamamoto K; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Kohara K; Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
  • Igase M; Department of Diabetes and Endocrinology, Chubu Rosai Hospital, Nagoya, 455-8530, Japan.
  • Han S; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
  • Gordon-Larsen P; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
  • Huang W; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
  • Lee NR; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan.
  • Adair LS; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, 470-0195, Japan.
  • Hwang MY; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, 830-0011, Japan.
  • Lee J; Faculty of Collaborative Regional Innovation, Ehime University, Matsuyama, 790-8577, Ehime, Japan.
  • Chee ML; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, 791-0295, Ehime, Japan.
  • Sabanayagam C; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, 363-951, Republic of Korea.
  • Zhao W; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Liu J; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
  • Reilly DF; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai, 201203, China.
  • Sun L; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, 6000, Philippines.
  • Huo S; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, 6000, Philippines.
Nat Commun ; 9(1): 5052, 2018 11 28.
Article in En | MEDLINE | ID: mdl-30487518
ABSTRACT
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Pressure Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Pressure Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Japan