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Increased expression of the TNF superfamily member LIGHT/TNFSF14 and its receptors (HVEM and LTßR) in patients with systemic sclerosis.
Gindzienska-Sieskiewicz, Ewa; Distler, Oliver; Reszec, Joanna; Jordan, Suzana; Bielecki, Pawel; Sieskiewicz, Andrzej; Sulik, Agnieszka; Lukasik, Malgorzata; Bielecki, Marek; Kowal, Krzysztof; Kowal-Bielecka, Otylia.
Affiliation
  • Gindzienska-Sieskiewicz E; Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Distler O; Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
  • Reszec J; Department of Medical Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
  • Jordan S; Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
  • Bielecki P; Department of Otolaryngology, Medical University of Bialystok, Bialystok, Poland.
  • Sieskiewicz A; Department of Otolaryngology, Medical University of Bialystok, Bialystok, Poland.
  • Sulik A; Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Lukasik M; Department of Medical Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
  • Bielecki M; Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland.
  • Kowal K; Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
  • Kowal-Bielecka O; Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.
Rheumatology (Oxford) ; 58(3): 502-510, 2019 03 01.
Article in En | MEDLINE | ID: mdl-30508197
ABSTRACT

OBJECTIVES:

This study aimed to assess the potential role of the TNF superfamily member lymphocyte T-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells (LIGHT) in SSc through evaluation of skin expression of LIGHT and its receptors, herpesvirus entry mediator and lymphotoxin ß-related receptor, and serum concentration of LIGHT in SSc patients.

METHODS:

Expression of LIGHT and its receptors was investigated by immunohistochemistry and evaluated semi-quantitatively in skin biopsies from 19 SSc patients and 9 healthy controls. Serum levels of LIGHT were measured using ELISA in 329 patients with SSc and 50 control subjects.

RESULTS:

Expression of LIGHT and both receptors was higher in SSc patients compared with controls (P < 0.05 for all comparisons). Patients with early SSc (⩽ 3 years from the first non-Raynaud's phenomenon symptom) showed higher expression of LIGHT and herpesvirus entry mediator compared with patients with longer disease duration (P < 0.05 for both comparisons). The mean serum concentration of LIGHT was significantly higher in SSc patients compared with the controls (P < 0.05). High serum concentration of LIGHT was associated with male sex, presence of digital ulcers, muscle involvement (defined by elevated serum creatine kinase levels), steroid treatment and lack of ACA. However, in multivariate regression analysis only presence of digital ulcers and creatine kinase elevation were independently associated with serum concentration of LIGHT.

CONCLUSION:

These data provide the first evidence of overexpression of LIGHT and its receptors in SSc and suggest that the LIGHT axis might contribute to the pathogenesis of SSc. Increased serum concentrations of LIGHT seem to reflect vascular injury in SSc.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scleroderma, Systemic / Skin / Tumor Necrosis Factor Ligand Superfamily Member 14 / Lymphotoxin beta Receptor / Receptors, Tumor Necrosis Factor, Member 14 Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2019 Document type: Article Affiliation country: Poland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Scleroderma, Systemic / Skin / Tumor Necrosis Factor Ligand Superfamily Member 14 / Lymphotoxin beta Receptor / Receptors, Tumor Necrosis Factor, Member 14 Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2019 Document type: Article Affiliation country: Poland