SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.

Fujino, Tomofumi; Yokokawa, Rina; Oshima, Toshiyuki; Hayakawa, Makio

Fujino, Tomofumi; Yokokawa, Rina; Oshima, Toshiyuki; Hayakawa, Makio.

Affiliation

Fujino T; Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.
Yokokawa R; Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.
Oshima T; Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.
Hayakawa M; Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan.

J Toxicol Sci ; 43(12): 711-715, 2018.

Article in En | MEDLINE | ID: mdl-30518708

Subject(s)

Carcinoma, Renal Cell/metabolism; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Kidney/metabolism; Sirtuin 1/genetics; Tumor Suppressor Protein p53/metabolism; Cell Line; Cyclin-Dependent Kinase Inhibitor p21/genetics; Gene Knockdown Techniques; Humans; RNA, Messenger/metabolism; Sirtuin 1/metabolism; Tumor Suppressor Protein p53/genetics; Up-Regulation

Key words

Carcinoma-specific cytotoxicity; Cyclin-dependent kinase inhibitor; Deacetylase-independent; SIRT1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Tumor Suppressor Protein p53 / Cyclin-Dependent Kinase Inhibitor p21 / Sirtuin 1 / Kidney Limits: Humans Language: En Journal: J Toxicol Sci Year: 2018 Document type: Article Affiliation country: Japan Country of publication: Japan

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