Monoamine Oxidase Inhibitory Activity of Biflavonoids from Branches of Garcinia gardneriana (Clusiaceae).
Nat Prod Commun
; 12(4): 505-508, 2017 Apr.
Article
in En
| MEDLINE
| ID: mdl-30520583
ABSTRACT
Garcinia gardneriana is chemically characterized by the presence of biflavonoids. Taking into account that flavonoids are able to inhibit monoamine oxidase (MAO) activity, in the present study, the chemical composition of the branches' extract of the plant is described for the first time and the MAO inhibitory . activity of the isolated biflavonoids was evaluated. Based on spectroscopic and spectrometric data, it was possible to identify volkesiflavone, morelloflavone (1), Gb-2a (2) and Gb-2a-7-Ο-glucoside (3) in the ethyl acetate fraction from ethanol extract of the branches. Compounds 1-3 were evaluated in vitro and demonstrated the capacity to inhibit MAO-A activity with an IC50 ranging from 5.05 to 10.7 µM, and from 20.7 to 66.2 µM for MAO-B. These inhibitions corroborate with previous IC50 obtained for monomeric flavonoids, with a higher selectivity for MAO-A isoform. The obtained results indicate that biflavonoids might be promising structures for the identification of new MAO inhibitory compounds.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Garcinia
/
Biflavonoids
/
Monoamine Oxidase
/
Monoamine Oxidase Inhibitors
Limits:
Humans
Language:
En
Journal:
Nat Prod Commun
Journal subject:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Year:
2017
Document type:
Article