Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?
Am J Physiol Lung Cell Mol Physiol
; 316(2): L369-L384, 2019 02 01.
Article
in En
| MEDLINE
| ID: mdl-30520687
ABSTRACT
Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells that can generate oxidants and are known to display aberrant polarization patterns and defective phagocytic responses in these diseases. Whether these characteristics are linked in one way or another and whether they contribute to the onset and severity of exacerbations in asthma and COPD remain poorly understood. Insight into oxidative stress, macrophages, and their interactions may be important in fully understanding acute worsening of lung disease. This review therefore highlights the current state of the art regarding the role of oxidative stress and macrophages in exacerbations of asthma and COPD. It shows that oxidative stress can attenuate macrophage function, which may result in impaired responses toward exacerbating triggers and may contribute to exaggerated inflammation in the airways.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Oxidative Stress
/
Pulmonary Disease, Chronic Obstructive
/
Macrophages
Limits:
Humans
Language:
En
Journal:
Am J Physiol Lung Cell Mol Physiol
Journal subject:
BIOLOGIA MOLECULAR
/
FISIOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Netherlands