Cutibacterium acnes in Spine Pathology: Pathophysiology, Diagnosis, and Management.
J Am Acad Orthop Surg
; 27(14): e633-e640, 2019 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-30520801
ABSTRACT
Cutibacterium acnes, long thought to be skin flora of pathological insignificance, has seen a surge in interest for its role in spine pathology. C acnes has been identified as a pathogen in native spine infection and osteomyelitis, which has implications in the management compared with more commonly recognized pathogens. In addition, It has also been recognized as a pathogen in postoperative and implant-associated infections. Some evidence exists pointing to C acnes as an unrecognized source of otherwise aseptic pseudarthrosis. Recently, it is hypothesized that low virulent organisms, in particular C acnes, may play a role in degenerative disk disease and the development of Modic end plate changes found in MRI. To this end, controversial implications exist in terms of the use of antibiotics to treat certain patients in the setting of degenerative disk disease. C acnes continues to remain an expanding area of interest in spine pathology, with important implications for the treating spine surgeon.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteomyelitis
/
Propionibacteriaceae
/
Spondylitis
/
Actinomycetales Infections
/
Intervertebral Disc Degeneration
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Am Acad Orthop Surg
Journal subject:
ORTOPEDIA
Year:
2019
Document type:
Article