Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice.
Regen Ther
; 9: 45-57, 2018 Dec.
Article
in En
| MEDLINE
| ID: mdl-30525075
8-OHdG, 8-hydroxydeoxyguanosine; A1AT, α1-antitrypsin; ALT, alanine aminotransferase; APOE, apolipoprotein E; AREG, amphiregulin; AST, aspartate aminotransferase; Acute liver failure; BM-MSCs, bone marrow-derived mesenchymal stem cells; C3, complement C3; C4A, complement C4A; C5aR, complement C5a receptor; CBP, CREB-binding protein; CCl4, carbon tetrachloride; CP, ceruloplasmin; ChREBP, Carbohydrate-responsive element-binding protein; ChoREs, carbohydrate response elements; DMSO, dimethyl sulfoxide; EGFR, epidermal growth factor receptor; ERK, extracellular signal-regulated kinase; GPX, glutathione peroxidase; GR, Glutathione reductase; GRX, glutaredoxin; GSH, glutathione; HB-EGF, heparin binding-epidermal growth factor-like growth factor; HGFR, hepatocyte growth factor receptor; Hepatic cell sheets; IL-1ra, interleukin-1 receptor antagonist; IL-6, interleukin-6; LXR, liver X receptor; Liver regeneration; MDA, malondialdehyde; Mesenchymal stem cells; NF-κB, nuclear factor-kappa B; PCNA, proliferating cell nuclear antigen; PRX, peroxiredoxin; RBP4, retinol binding protein 4; SOD, superoxide dismutase; STAT-3, Signal Tranducer and Activator of Transcription 3; TF, transferrin; TGFα, transforming growth factor alpha; TNFα, tumor necrosis factor alpha; TRX, thioredoxin; TRXR, thioredoxin reductase; Wnt/ß-catenin signal inhibitor; hGAPDH, human glyceraldehyde 3-phosphate dehydrogenase; mActb, mouse actin, beta
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Regen Ther
Year:
2018
Document type:
Article
Affiliation country:
Japan
Country of publication:
Netherlands