Mechanical loading releases osteoclastogenesis-modulating factors through stimulation of the P2X7 receptor in hematopoietic progenitor cells.

Bratengeier, Cornelia; Bakker, Astrid D; Fahlgren, Anna

Bratengeier, Cornelia; Bakker, Astrid D; Fahlgren, Anna.

Affiliation

Bratengeier C; Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden.
Bakker AD; Department of Oral Cell Biology, ACTA, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Fahlgren A; Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden.

J Cell Physiol ; 234(8): 13057-13067, 2019 08.

Article in En | MEDLINE | ID: mdl-30536959

Subject(s)

Cell Differentiation/physiology; Hematopoietic Stem Cells/metabolism; Osteoclasts/metabolism; Osteogenesis/physiology; Receptors, Purinergic P2X7/metabolism; Stress, Mechanical; Animals; Male; Mice; Mice, Inbred C57BL; Prosthesis Failure

Key words

fluid flow; implant loosening; mechanoresponsive hematopoietic progenitor cells; osteolysis; purinergic signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Osteogenesis / Stress, Mechanical / Hematopoietic Stem Cells / Cell Differentiation / Receptors, Purinergic P2X7 Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Physiol Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: United States

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