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Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.
Haberman, Yael; Schirmer, Melanie; Dexheimer, Phillip J; Karns, Rebekah; Braun, Tzipi; Kim, Mi-Ok; Walters, Thomas D; Baldassano, Robert N; Noe, Joshua D; Rosh, Joel; Markowitz, James; Crandall, Wallace V; Mack, David R; Griffiths, Anne M; Heyman, Melvin B; Baker, Susan S; Kellermayer, Richard; Moulton, Dedrick; Patel, Ashish S; Gulati, Ajay S; Steiner, Steven J; LeLeiko, Neal; Otley, Anthony; Oliva-Hemker, Maria; Ziring, David; Kirschner, Barbara S; Keljo, David J; Guthery, Stephen L; Cohen, Stanley A; Snapper, Scott; Evans, Jonathan; Dubinsky, Marla; Aronow, Bruce; Hyams, Jeffrey S; Kugathasan, Subra; Huttenhower, Curtis; Xavier, Ramnik J; Denson, Lee A.
Affiliation
  • Haberman Y; Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Yael.haberman@cchmc.org.
  • Schirmer M; Sheba Medical Center, Tel-HaShomer, affiliated with the Tel-Aviv University, Tel-Aviv, Israel. Yael.haberman@cchmc.org.
  • Dexheimer PJ; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Karns R; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Braun T; Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Kim MO; Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Walters TD; Sheba Medical Center, Tel-HaShomer, affiliated with the Tel-Aviv University, Tel-Aviv, Israel.
  • Baldassano RN; Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Noe JD; Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Rosh J; The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Markowitz J; Medical College of Wisconsin, Milwaukee, WI, USA.
  • Crandall WV; Goryeb Children's Hospital/Atlantic Health, Morristown, NJ, USA.
  • Mack DR; Cohen Children's Medical Center of New York, New Hyde Park, New York, NY, USA.
  • Griffiths AM; Nationwide Children's Hospital, Columbus, OH, USA.
  • Heyman MB; Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
  • Baker SS; Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Kellermayer R; University of California San Francisco, San Francisco, CA, USA.
  • Moulton D; University at Buffalo, Buffalo, NY, USA.
  • Patel AS; Texas Children's Hospital, Baylor College School of Medicine, Houston, TX, USA.
  • Gulati AS; Vanderbilt Children's Hospital, Nashville, TN, USA.
  • Steiner SJ; UT Southwestern Medical Center at Dallas, Dallas, TX, USA.
  • LeLeiko N; University of North Carolina, Chapel Hill, NC, USA.
  • Otley A; Riley Children's Hospital, Indiannapolis, IN, USA.
  • Oliva-Hemker M; Hasbro Children's Hospital, Providence, RI, USA.
  • Ziring D; IWK Health Centre, Halifax, NS, Canada.
  • Kirschner BS; John Hopkins University, Baltimore, MD, USA.
  • Keljo DJ; Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Guthery SL; University of Chicago Comer Children's Hospital, Chicago, IL, USA.
  • Cohen SA; Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
  • Snapper S; University of Utah, Salt Lake City, UT, USA.
  • Evans J; Children's Center for Digestive HealthMedicine, Atlanta, GA, USA.
  • Dubinsky M; Children's Hospital - Boston, Boston, MA, USA.
  • Aronow B; Nemours Children's Clinic, Jacksonville, FL, USA.
  • Hyams JS; Mount Sinai Hospital New York, New York, NY, USA.
  • Kugathasan S; Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Huttenhower C; Connecticut Children's Medical Center, Hartford, CT, USA.
  • Xavier RJ; Emory University, Atlanta, GA, USA.
  • Denson LA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mucosal Immunol ; 12(2): 491-502, 2019 03.
Article in En | MEDLINE | ID: mdl-30542108

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peyer's Patches / Aging / Crohn Disease / Age Factors / Alpha-Defensins / Dysbiosis / Ileum Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Mucosal Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peyer's Patches / Aging / Crohn Disease / Age Factors / Alpha-Defensins / Dysbiosis / Ileum Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: Mucosal Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States