ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth.

Khan, Iman Aftab; Yoo, Byong Hoon; McPhee, Michael; Masson, Olivier; Surette, Alexi; Dakin-Hache, Kelly; Younis, Tallal; Bethune, Gillian; Rosen, Kirill V

Khan, Iman Aftab; Yoo, Byong Hoon; McPhee, Michael; Masson, Olivier; Surette, Alexi; Dakin-Hache, Kelly; Younis, Tallal; Bethune, Gillian; Rosen, Kirill V.

Affiliation

Khan IA; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Yoo BH; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
McPhee M; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Masson O; Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Surette A; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Dakin-Hache K; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada.
Younis T; Department of Pathology, Dalhousie University, Halifax, NS, Canada.
Bethune G; Department of Pathology, Dalhousie University, Halifax, NS, Canada.
Rosen KV; Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Breast Cancer Res ; 20(1): 151, 2018 12 13.

Article in En | MEDLINE | ID: mdl-30545388

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/pathology; Cell Transformation, Neoplastic/pathology; Interferon Regulatory Factors/metabolism; Receptor, ErbB-2/metabolism; Anoikis/drug effects; Antineoplastic Agents/therapeutic use; Biopsy; Breast/cytology; Breast/pathology; Breast Neoplasms/drug therapy; Cell Culture Techniques; Cell Line; Cohort Studies; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Extracellular Matrix/metabolism; Extracellular Matrix/pathology; Female; Humans; Interferon Regulatory Factors/genetics; Neoadjuvant Therapy/methods; Pilot Projects; RNA, Small Interfering/metabolism; Receptor, ErbB-2/antagonists & inhibitors; Trastuzumab/pharmacology; Trastuzumab/therapeutic use; Up-Regulation/drug effects

Key words

Anoikis; Apoptosis; Breast cancer; ErbB2; Irf6

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Cell Transformation, Neoplastic / Receptor, ErbB-2 / Interferon Regulatory Factors / Antineoplastic Agents Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: Breast Cancer Res Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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