Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones.
J Org Chem
; 84(2): 769-779, 2019 01 18.
Article
in En
| MEDLINE
| ID: mdl-30548070
ABSTRACT
Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcohols yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alcohol, and naproxen alcohol were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Guideline
Language:
En
Journal:
J Org Chem
Year:
2019
Document type:
Article
Affiliation country:
India