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p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Moon, Sung-Hwan; Huang, Chun-Hao; Houlihan, Shauna L; Regunath, Kausik; Freed-Pastor, William A; Morris, John P; Tschaharganeh, Darjus F; Kastenhuber, Edward R; Barsotti, Anthony M; Culp-Hill, Rachel; Xue, Wen; Ho, Yu-Jui; Baslan, Timour; Li, Xiang; Mayle, Allison; de Stanchina, Elisa; Zender, Lars; Tong, David R; D'Alessandro, Angelo; Lowe, Scott W; Prives, Carol.
Affiliation
  • Moon SH; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  • Huang CH; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring
  • Houlihan SL; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Regunath K; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  • Freed-Pastor WA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  • Morris JP; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Tschaharganeh DF; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kastenhuber ER; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Barsotti AM; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  • Culp-Hill R; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Xue W; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Ho YJ; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Baslan T; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Li X; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
  • Mayle A; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • de Stanchina E; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Zender L; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Tong DR; Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  • D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Lowe SW; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: lowes@mskcc.org.
  • Prives C; Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: clp3@columbia.edu.
Cell ; 176(3): 564-580.e19, 2019 01 24.
Article in En | MEDLINE | ID: mdl-30580964
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Mevalonic Acid Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Cell Year: 2019 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Mevalonic Acid Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Cell Year: 2019 Document type: Article Affiliation country: United States