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The P-glycoprotein inhibitor diltiazem-like 8-(4-chlorophenyl)-5-methyl-8-[(2Z)-pent-2-en-1-yloxy]-8H-[1,2,4]oxadiazolo[3,4-c][1,4]thiazin-3-one inhibits esterase activity and H3 histone acetylation.
Cuviello, Flavia; Bisaccia, Faustino; Spinelli, Domenico; Armentano, Maria Francesca; Bufo, Sabino Aurelio; Cosimelli, Barbara; Ostuni, Angela.
Affiliation
  • Cuviello F; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
  • Bisaccia F; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
  • Spinelli D; Department of Chemistry "G. Ciamician", Alma Mater Studiorum-University of Bologna, Via F. Selmi 2, Bologna, 40126, Italy.
  • Armentano MF; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
  • Bufo SA; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy.
  • Cosimelli B; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131, Napoli, 80131, Italy. Electronic address: barbara.cosimelli@unina.it.
  • Ostuni A; Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, Potenza, 85100, Italy. Electronic address: angela.ostuni@unibas.it.
Eur J Med Chem ; 164: 1-7, 2019 Feb 15.
Article in En | MEDLINE | ID: mdl-30583246
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazines / Diltiazem / Histones / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Esterases Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: Italy Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazines / Diltiazem / Histones / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Esterases Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Document type: Article Affiliation country: Italy Country of publication: France