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Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.
Zhang, Chenzi; He, Xiangjun; Kwok, Yvonne K; Wang, Feng; Xue, Junyi; Zhao, Hui; Suen, Kin Wah; Wang, Chi Chiu; Ren, Jianwei; Chen, George G; Lai, Paul B S; Li, Jiangchao; Xia, Yin; Chan, Andrew M; Chan, Wai-Yee; Feng, Bo.
Affiliation
  • Zhang C; School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • He X; School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Kwok YK; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Wang F; School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Xue J; School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Zhao H; Institute for Tissue Engineering and Regenerative Medicine (iTERM), The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Suen KW; SBS Core Laboratory, CUHK Shenzhen Research Institute, Shenzhen, 518057, China.
  • Wang CC; School of Biomedical Sciences, CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Ren J; Institute for Tissue Engineering and Regenerative Medicine (iTERM), The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Chen GG; SBS Core Laboratory, CUHK Shenzhen Research Institute, Shenzhen, 518057, China.
  • Lai PBS; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Li J; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Xia Y; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Chan AM; Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Chan WY; Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
  • Feng B; State Key Laboratory in Oncology in South China, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China.
BMC Biol ; 16(1): 151, 2018 12 28.
Article in En | MEDLINE | ID: mdl-30593266
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Ubiquitins / Carrier Proteins / Intracellular Signaling Peptides and Proteins / DNA Repair / Gene Knock-In Techniques / CRISPR-Cas Systems / Autophagy-Related Protein-1 Homolog Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2018 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Ubiquitins / Carrier Proteins / Intracellular Signaling Peptides and Proteins / DNA Repair / Gene Knock-In Techniques / CRISPR-Cas Systems / Autophagy-Related Protein-1 Homolog Language: En Journal: BMC Biol Journal subject: BIOLOGIA Year: 2018 Document type: Article Country of publication: United kingdom