Helicase Subunit Cdc45 Targets the Checkpoint Kinase Rad53 to Both Replication Initiation and Elongation Complexes after Fork Stalling.

Can, Geylani; Kauerhof, Anastasia Christine; Macak, Dominik; Zegerman, Philip

Can, Geylani; Kauerhof, Anastasia Christine; Macak, Dominik; Zegerman, Philip.

Affiliation

Can G; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK.
Kauerhof AC; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK.
Macak D; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK.
Zegerman P; Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address: p.zegerman@gurdon.cam.ac.uk.

Mol Cell ; 73(3): 562-573.e3, 2019 02 07.

Article in En | MEDLINE | ID: mdl-30595439

Subject(s)

Cell Cycle Proteins/metabolism; Checkpoint Kinase 2/metabolism; DNA Damage; DNA Repair; DNA Replication; DNA, Fungal/biosynthesis; DNA-Binding Proteins/metabolism; Nuclear Proteins/metabolism; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Cell Cycle Proteins/genetics; Checkpoint Kinase 2/genetics; Congenital Microtia/enzymology; Congenital Microtia/genetics; DNA, Fungal/genetics; DNA-Binding Proteins/genetics; Growth Disorders/enzymology; Growth Disorders/genetics; Humans; Micrognathism/enzymology; Micrognathism/genetics; Mutation; Nuclear Proteins/genetics; Patella/abnormalities; Patella/enzymology; Phosphorylation; Protein Binding; S Phase Cell Cycle Checkpoints; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae Proteins/genetics

Key words

Cdc45; DNA damage; DNA replication; Rad53; budding yeast; checkpoint; replisome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / DNA Damage / DNA, Fungal / Nuclear Proteins / Cell Cycle Proteins / Saccharomyces cerevisiae Proteins / DNA-Binding Proteins / DNA Repair / DNA Replication / Checkpoint Kinase 2 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: United States

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