VIVD: Virtual in vitro distribution model for the mechanistic prediction of intracellular concentrations of chemicals in in vitro toxicity assays.

Fisher, C; Siméon, S; Jamei, M; Gardner, I; Bois, Y F

Fisher, C; Siméon, S; Jamei, M; Gardner, I; Bois, Y F.

Affiliation

Fisher C; Certara UK Limited, Simcyp Division, Acero, 1 Concourse Way, Sheffield S1 2BJ, UK. Electronic address: ciaran.fisher@certara.com.
Siméon S; INERIS, METO Unit, Verneuil en Halatte, France.
Jamei M; Certara UK Limited, Simcyp Division, Acero, 1 Concourse Way, Sheffield S1 2BJ, UK.
Gardner I; Certara UK Limited, Simcyp Division, Acero, 1 Concourse Way, Sheffield S1 2BJ, UK.
Bois YF; INERIS, METO Unit, Verneuil en Halatte, France.

Toxicol In Vitro ; 58: 42-50, 2019 Aug.

Article in En | MEDLINE | ID: mdl-30599189

Subject(s)

Hepatocytes/metabolism; Models, Biological; Pharmaceutical Preparations/metabolism; Cell Culture Techniques/instrumentation; Cell Membrane/physiology; Cell Membrane Permeability; Cells, Cultured; Hepatocytes/physiology; Humans; Hydrogen-Ion Concentration; Lipid Metabolism; Pharmaceutical Preparations/chemistry; Plastics/chemistry; Protein Binding; Toxicity Tests; Volatilization

Key words

Biokinetics; IVIVE; In vitro assays; Toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Hepatocytes / Models, Biological Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2019 Document type: Article Country of publication: United kingdom

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