MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.

Arifuzzaman, Mohammad; Mobley, Yuvon R; Choi, Hae Woong; Bist, Pradeep; Salinas, Cristina A; Brown, Zachary D; Chen, Swaine L; Staats, Herman F; Abraham, Soman N

Arifuzzaman, Mohammad; Mobley, Yuvon R; Choi, Hae Woong; Bist, Pradeep; Salinas, Cristina A; Brown, Zachary D; Chen, Swaine L; Staats, Herman F; Abraham, Soman N.

Affiliation

Arifuzzaman M; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
Mobley YR; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.
Choi HW; Department of Pathology, Duke University, Durham, NC 27710, USA.
Bist P; Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore.
Salinas CA; Undergraduate Program in Biology, Duke University, Durham, NC 27710, USA.
Brown ZD; Undergraduate Program in Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Chen SL; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Staats HF; Infectious Diseases Group, Genome Institute of Singapore, Singapore 138672, Singapore.
Abraham SN; Department of Pathology, Duke University, Durham, NC 27710, USA.

Sci Adv ; 5(1): eaav0216, 2019 01.

Article in En | MEDLINE | ID: mdl-30613778

Subject(s)

Mast Cells/immunology; Mast Cells/metabolism; Nerve Tissue Proteins/metabolism; Receptors, G-Protein-Coupled/metabolism; Receptors, Neuropeptide/metabolism; Staphylococcal Skin Infections/immunology; Staphylococcal Skin Infections/metabolism; Adaptive Immunity/drug effects; Administration, Topical; Animals; Dendritic Cells/immunology; Dendritic Cells/metabolism; Female; HEK293 Cells; Humans; Intercellular Signaling Peptides and Proteins/administration & dosage; Intercellular Signaling Peptides and Proteins/therapeutic use; Male; Mast Cells/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins/genetics; Neutrophils/immunology; Neutrophils/metabolism; Receptors, G-Protein-Coupled/genetics; Receptors, Neuropeptide/genetics; Staphylococcal Skin Infections/drug therapy; Staphylococcal Skin Infections/microbiology; Staphylococcus aureus/drug effects; Staphylococcus aureus/growth & development; Transfection; Wasp Venoms/administration & dosage; Wasp Venoms/therapeutic use; Wound Healing/drug effects; Wound Healing/immunology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Skin Infections / Receptors, Neuropeptide / Receptors, G-Protein-Coupled / Mast Cells / Nerve Tissue Proteins Limits: Animals / Female / Humans / Male Language: En Journal: Sci Adv Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google