Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor.

Ku, Yi-Yin; Chan, Vincent S; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D

Ku, Yi-Yin; Chan, Vincent S; Christesen, Alan; Grieme, Timothy; Mulhern, Mathew; Pu, Yu-Ming; Wendt, Michael D.

J Org Chem ; 84(8): 4814-4829, 2019 04 19.

Article in En | MEDLINE | ID: mdl-30615835

Subject(s)

Antineoplastic Agents/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Sulfonamides/pharmacology; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis; Bridged Bicyclo Compounds, Heterocyclic/chemistry; Humans; Molecular Structure; Proto-Oncogene Proteins c-bcl-2/metabolism; Sulfonamides/chemical synthesis; Sulfonamides/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 / Antineoplastic Agents Limits: Humans Language: En Journal: J Org Chem Year: 2019 Document type: Article Country of publication: United States

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