SMOFlipid Protects Preterm Neonates against Perinatal Nutrition-Associated Cholestasis.
Am J Perinatol
; 36(13): 1382-1386, 2019 11.
Article
in En
| MEDLINE
| ID: mdl-30620942
OBJECTIVE: Intravenous lipid infusions improve both short- and long-term outcomes of premature neonates. However, prolonged infusion of lipids has been implicated in the development of parenteral nutrition-associated cholestasis (PNAC). We speculated that the multicomponent SMOFlipid would be hepatoprotective against PNAC. STUDY DESIGN: This is a retrospective review comparing the incidence and severity of direct hyperbilirubinemia in preterm infants <1,500 g who were hospitalized for a minimum of 2 weeks during a 20-month period in which all preterm infants on total parenteral nutrition (TPN) received fat as Lipofundin with the following 20-month period in which all preterm infants on TPN received SMOFlipid. RESULTS: Infants in the SMOFlipid period had a lower incidence of PNAC (6 vs. 13%; p = 0.022), lower peak direct bilirubin levels (3.2 vs. 7.1 mg/dL; p = 0.018), and a shorter length of stay (51 vs. 60 days; p = 0.019). The relative risk of developing direct hyperbilirubinemia during the Lipofundin period was 2.22 (1.1-4.3) as compared with period 1; p = 0.018; NNT-14. CONCLUSION: SMOFlipid was hepatoprotective in our population of preterm neonates <1,500 g receiving long-term TPN as compared with those receiving Lipofundin, despite similar levels of exposure to both intravenous lipid load and duration in the two groups.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipids
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Sorbitol
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Triglycerides
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Soybean Oil
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Fish Oils
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Cholestasis
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Parenteral Nutrition, Total
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Hyperbilirubinemia, Neonatal
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Fat Emulsions, Intravenous
/
Olive Oil
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Am J Perinatol
Year:
2019
Document type:
Article
Affiliation country:
Israel
Country of publication:
United States