Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers.

Dasari, Anvesh K R; Hughes, Robert M; Wi, Sungsool; Hung, Ivan; Gan, Zhehong; Kelly, Jeffrey W; Lim, Kwang Hun

Dasari, Anvesh K R; Hughes, Robert M; Wi, Sungsool; Hung, Ivan; Gan, Zhehong; Kelly, Jeffrey W; Lim, Kwang Hun.

Affiliation

Dasari AKR; Department of Chemistry, East Carolina University, Greenville, NC, 27858, USA.
Hughes RM; Department of Chemistry, East Carolina University, Greenville, NC, 27858, USA.
Wi S; Center of Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East, Paul Dirac Dr., Tallahassee, FL, 32310, USA.
Hung I; Center of Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East, Paul Dirac Dr., Tallahassee, FL, 32310, USA.
Gan Z; Center of Interdisciplinary Magnetic Resonance (CIMAR), National High Magnetic Field Laboratory (NHMFL), 1800 East, Paul Dirac Dr., Tallahassee, FL, 32310, USA.
Kelly JW; Department of Molecular and Experimental Medicine, the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lim KH; Department of Chemistry, East Carolina University, Greenville, NC, 27858, USA. limk@ecu.edu.

Sci Rep ; 9(1): 33, 2019 01 10.

Article in En | MEDLINE | ID: mdl-30631096

Subject(s)

Prealbumin/metabolism; Prealbumin/toxicity; Protein Aggregation, Pathological; Protein Denaturation; Protein Multimerization; Circular Dichroism; Magnetic Resonance Spectroscopy; Prealbumin/chemistry; Protein Conformation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Denaturation / Prealbumin / Protein Multimerization / Protein Aggregation, Pathological Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom

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