Cytotoxic Pathways in Allogeneic Hematopoietic Cell Transplantation.

Du, Wei; Cao, Xuefang

Du, Wei; Cao, Xuefang.

Affiliation

Du W; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Cao X; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.

Front Immunol ; 9: 2979, 2018.

Article in En | MEDLINE | ID: mdl-30631325

Subject(s)

Cytotoxicity, Immunologic; Graft vs Host Disease/immunology; Graft vs Tumor Effect/immunology; Hematologic Neoplasms/therapy; Hematopoietic Stem Cell Transplantation/adverse effects; Cytokines/immunology; Cytokines/metabolism; Fas Ligand Protein/immunology; Fas Ligand Protein/metabolism; Granzymes/immunology; Granzymes/metabolism; Hematologic Neoplasms/immunology; Humans; Isoantigens/immunology; Perforin/immunology; Perforin/metabolism; Signal Transduction/immunology; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/metabolism; Transplantation, Homologous/adverse effects; Treatment Outcome; fas Receptor/immunology; fas Receptor/metabolism

Key words

allogeneic hematopoietic cell transplantation (allo-HCT); cytokines; cytotoxic pathways; graft-vs.-host disease (GVHD); graft-vs.-tumor (GVT) effect; the Fas/Fas ligand (FasL) system; the perforin/granzyme pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Hematologic Neoplasms / Graft vs Tumor Effect / Cytotoxicity, Immunologic / Graft vs Host Disease Type of study: Prognostic_studies Limits: Humans Language: En Journal: Front Immunol Year: 2018 Document type: Article Affiliation country: United States Country of publication: Switzerland

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