Acne, the Skin Microbiome, and Antibiotic Treatment.
Am J Clin Dermatol
; 20(3): 335-344, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-30632097
ABSTRACT
Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Among them, Propionibacterium acnes and Malassezia spp. have been linked to acne development through their influence on sebum secretion, comedone formation, and inflammatory response. Antibiotics targeting P. acnes have been the mainstay in acne treatment for the past four decades. Among them, macrolides, clindamycin, and tetracyclines are the most widely prescribed. As antibiotic resistance becomes an increasing concern in clinical practice, understanding the skin microbiome associated with acne and the effects of antibiotic use on the skin commensals is highly relevant and critical to clinicians. In this review, we summarize recent studies of the composition and dynamics of the skin microbiome in acne and the effects of antibiotic treatment on skin microbes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acne Vulgaris
/
Drug Resistance, Bacterial
/
Microbiota
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Am J Clin Dermatol
Journal subject:
DERMATOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
United States