One hertz versus ten hertz repetitive TMS treatment of PTSD: A randomized clinical trial.
Psychiatry Res
; 273: 153-162, 2019 03.
Article
in En
| MEDLINE
| ID: mdl-30641346
ABSTRACT
The purpose of this trial was to test whether right prefrontal cortex 1â¯Hz versus 10â¯Hz rTMS provides a significantly greater improvement in PTSD symptoms and/or function. Veterans 18 to 50 years of age suffering from PTSD were randomized to right prefrontal 1â¯Hz rTMS [2400 pulses/session] versus right prefrontal 10â¯Hz rTMS [2400 pulses/session]. The treatments were performed 5 days a week for 6 weeks with a 3-week taper using the NeuroStar system. There were one month and three months post treatment follow-up evaluations. Forty-four participants were enrolled with 17 being randomized to 1â¯Hz rTMS and 18 to 10â¯Hz rTMS. Both groups had significant improvement in PTSD and depression scores from baseline to the end of acute treatment. The 10â¯Hz group but not the 1â¯Hz group demonstrated significant improvement in function. Although both groups demonstrated significant improvement in PTSD and depression symptoms, a significant advantage for either the 1â¯Hz or 10â¯Hz frequency group on any of the scales acquired was not demonstrated. Further work is required with larger samples sizes to test whether low or high frequency is superior or if individual differences would indicate the more effective frequency.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress Disorders, Post-Traumatic
/
Veterans
/
Transcranial Magnetic Stimulation
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Psychiatry Res
Year:
2019
Document type:
Article