IL-33 Is a Negative Regulator of Vaccine-Induced Antigen-Specific Cellular Immunity.
J Immunol
; 202(4): 1145-1152, 2019 02 15.
Article
in En
| MEDLINE
| ID: mdl-30642984
ABSTRACT
The cytokine IL-33 is a well-established inducer of Th2 responses. However, roles for IL-33 in promoting CD8, Th1, and T regulatory cell responses have also emerged. In this study, the role of IL-33 as a regulator of particulate vaccine adjuvant-induced Ag-specific cellular immunity was investigated. We found that polymeric nanoparticles surpassed alum in their ability to enhance Ag-specific CD8 and Th1 responses. IL-33 was a potent negative regulator of both CD8+ T cell and Th1 responses following i.m. vaccination with Ag and nanoparticles, whereas the cytokine was required for the nanoparticle enhancement in Ag-specific IL-10. In contrast to the effect on cellular immunity, Ab responses were comparable between vaccinated wild-type and IL-33-deficient mice. IL-33 did not compromise alum-induced adaptive cellular immunity after i.m. vaccination. These data suggest that IL-33 attenuates the induction of cellular immune responses by nanoparticulate adjuvants and should be considered in the rational design of vaccines targeting enhanced CD8 and Th1 responses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines
/
Interleukin-33
/
Immunity, Cellular
/
Antigens
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2019
Document type:
Article
Affiliation country:
Ireland