Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis.
Nat Commun
; 10(1): 190, 2019 01 14.
Article
in En
| MEDLINE
| ID: mdl-30643147
ABSTRACT
A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgDlow/- expression maintains tolerance by, at least in part, promoting CD4+Foxp3+ regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BDL) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. The cell surface phenotype and regulatory function of BDL are highly suggestive that they are a new B cell subset. Human splenic and peripheral blood IgDlow/- B cells also exhibit BDL regulatory activity, rendering them of therapeutic interest.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocyte Subsets
/
T-Lymphocytes, Regulatory
/
Gene Expression Regulation, Developmental
/
Dermatitis, Contact
/
Immune Tolerance
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2019
Document type:
Article
Affiliation country:
United States