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Alternation in dopamine D2-like and metabotropic glutamate type 5 receptor density caused by differing housing conditions during abstinence from cocaine self-administration in rats.
Frankowska, Malgorzata; Miszkiel, Joanna; Pomierny-Chamiolo, Lucyna; Pomierny, Bartosz; Giannotti, Giuseppe; Suder, Agata; Filip, Malgorzata.
Affiliation
  • Frankowska M; 1 Department of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
  • Miszkiel J; 1 Department of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
  • Pomierny-Chamiolo L; 2 Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, Kraków, Poland.
  • Pomierny B; 2 Department of Toxicology, Faculty of Pharmacy, Jagiellonian University Collegium Medicum, Kraków, Poland.
  • Giannotti G; 3 Department of Pharmacological and Bimolecular Sciences, University of Milan, Milan, Italy.
  • Suder A; 1 Department of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
  • Filip M; 1 Department of Drug Addiction Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
J Psychopharmacol ; 33(3): 372-382, 2019 03.
Article in En | MEDLINE | ID: mdl-30644313
BACKGROUND: Environmental conditions have an important function in substance use disorder, increasing or decreasing the risks of relapse. Several studies strongly support the role of the dopamine D2-like and metabotropic glutamate type 5 receptors in maladaptive neurobiological responses to cocaine reward and relapse. AIMS: The present study employed cocaine self-administration with yoked-triad procedure in rats to explore whether drug abstinence in different housing conditions affects the drug-seeking behaviour and the dopamine D2-like and metabotropic glutamate type 5 receptor density and affinity in several regions of the animal brain. METHODS: Rats were trained to self-administer cocaine and later they were forced to abstain either in: (a) enriched environment or (b) isolation cage conditions to evaluate the effect of housing conditions on the drug-seeking behaviour and to assess changes concerning receptors in animals brain. RESULTS: Our results show that exposure to enriched environment conditions strongly reduced active lever presses during cue-induced drug-seeking. At the neurochemical level, we demonstrated a significant increase in the dopamine D2-like receptor density in the prefrontal cortex in animals following drug abstinence in isolation cage or enriched environment conditions, and the reduction in their density in the dorsal striatum provoked by isolation cage conditions. The metabotropic glutamate type 5 receptor density decreased only in the prefrontal cortex after isolation cage and enriched environment abstinence. CONCLUSIONS: This study shows the different impacts caused by the type of housing conditions during abstinence from cocaine self-administration on drug-seeking behaviour in rats. The observed changes in the dopamine D2-like and metabotropic glutamate type 5 receptor Bmax and/or Kd values were brain-region specific and related to either pharmacological and/or motivational features of cocaine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Dopamine D2 / Cocaine / Cocaine-Related Disorders / Receptor, Metabotropic Glutamate 5 Limits: Animals Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Poland Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Dopamine D2 / Cocaine / Cocaine-Related Disorders / Receptor, Metabotropic Glutamate 5 Limits: Animals Language: En Journal: J Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Poland Country of publication: United States