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Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma.
Carlsson, Mats; Braddock, Martin; Li, Yuling; Wang, Jihong; Xu, Weichen; White, Nicholas; Megally, Ayman; Hunter, Gillian; Colice, Gene.
Affiliation
  • Carlsson M; Patient Safety, Global Medicines Development, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden. Mats.Carlsson@astrazeneca.com.
  • Braddock M; Global Medicines Development, AstraZeneca, Granta Park, Great Abington, Cambridge, CB21 6GH, UK.
  • Li Y; Biopharmaceutical Development, MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Wang J; Biopharmaceutical Development, MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Xu W; Biopharmaceutical Development, MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • White N; Clinical Pharmacology, Pharmacometrics and DMPK, MedImmune, Granta Park, Great Abington, Cambridge, CB21 6GH, UK.
  • Megally A; Global Medicines Development, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Hunter G; Biometrics and Information Sciences, AstraZeneca, Granta Park, Great Abington, Cambridge, CB21 6GH, UK.
  • Colice G; Global Medicines Development, AstraZeneca, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Drug Saf ; 42(6): 769-784, 2019 06.
Article in En | MEDLINE | ID: mdl-30649752

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Drug Hypersensitivity / Anaphylaxis / Antibodies, Monoclonal / Antibody Formation Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Language: En Journal: Drug Saf Journal subject: TERAPIA POR MEDICAMENTOS / TOXICOLOGIA Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: New Zealand

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Drug Hypersensitivity / Anaphylaxis / Antibodies, Monoclonal / Antibody Formation Type of study: Clinical_trials Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Language: En Journal: Drug Saf Journal subject: TERAPIA POR MEDICAMENTOS / TOXICOLOGIA Year: 2019 Document type: Article Affiliation country: Sweden Country of publication: New Zealand