Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus.
Turk Neurosurg
; 29(3): 430-433, 2019.
Article
in En
| MEDLINE
| ID: mdl-30649828
ABSTRACT
AIM:
To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinsonâ™s disease (PD) who underwent deep brain stimulation of the subthalamic nucleus. MATERIAL ANDMETHODS:
MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.RESULTS:
MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05).CONCLUSION:
MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Motor Skills Disorders
/
Subthalamic Nucleus
/
Deep Brain Stimulation
/
Intraoperative Neurophysiological Monitoring
Type of study:
Diagnostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Turk Neurosurg
Journal subject:
NEUROCIRURGIA
Year:
2019
Document type:
Article
Affiliation country:
Turkey