Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does not.
Respir Res
; 20(1): 12, 2019 Jan 17.
Article
in En
| MEDLINE
| ID: mdl-30654798
ABSTRACT
BACKGROUND:
While continuous exercise (CE) induces greater ventilation ([Formula see text]E) when compared to intermittent exercise (IE), little is known of the consequences on airway damage. Our aim was to investigate markers of epithelial cell damage - i.e. serum levels of CC16 and of the CC16/SP-D ratio - during and following a bout of CE and IE of matched work.METHODS:
Sixteen healthy young adults performed a 30-min continuous (CE) and a 60-min intermittent exercise (IE; 1-min work 1-min rest) on separate occasions in a random order. Intensity was set at 70% of their maximum work rate (WRmax). Heart rate (HR) and [Formula see text]E were measured throughout both tests. Blood samples were taken at rest, after the 10th min of the warm-up, at the end of both exercises, half way through IE (matched time but 50% work done for IE) as well as 30- and 60-min post-exercise. Lactate and CC16 and SP-D were determined.RESULTS:
Mean [Formula see text]E was higher for CE compared to IE (85 ± 17 l.min- 1 vs 50 ± 8 l.min- 1, respectively; P < 0.001). Serum-based markers of epithelial cell damage remained unchanged during IE. Interaction of test × time was observed for SP-D (P = 0.02), CC16 (µg.l- 1) (P = 0.006) and CC16/SP-D ratio (P = 0.03). Maximum delta CC16/SP-D was significantly correlated with mean [Formula see text]E sustained (r = 0.83, P < 0.001) during CE but not during IE.CONCLUSION:
The 30-min CE performed at 70% WRmax induced mild airway damage, while a time- or work-matched IE did not. The extent of the damage during CE was associated with the higher ventilation rate.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Exercise
/
Inflammation Mediators
/
Respiratory Mucosa
/
Exercise Test
/
Respiratory Rate
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Respir Res
Year:
2019
Document type:
Article
Affiliation country:
France