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Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM.
Matheson, Elizabeth C; Thomas, Huw; Case, Marian; Blair, Helen; Jackson, Rosanna K; Masic, Dino; Veal, Gareth; Halsey, Chris; Newell, David R; Vormoor, Josef; Irving, Julie A E.
Affiliation
  • Matheson EC; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Thomas H; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Case M; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Blair H; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Jackson RK; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Masic D; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Veal G; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Halsey C; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow.
  • Newell DR; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Vormoor J; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
  • Irving JAE; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Haematologica ; 104(9): 1804-1811, 2019 09.
Article in En | MEDLINE | ID: mdl-30655370

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Ras Proteins / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Bcl-2-Like Protein 11 / Glucocorticoids Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male Language: En Journal: Haematologica Year: 2019 Document type: Article Country of publication: Italy

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Ras Proteins / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Bcl-2-Like Protein 11 / Glucocorticoids Limits: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male Language: En Journal: Haematologica Year: 2019 Document type: Article Country of publication: Italy