Analysis of motor and respiratory function in Duchenne muscular dystrophy patients.

ABSTRACT

INTRODUCTION: Duchenne muscular dystrophy(DMD) shows motor and respiratory impairment. METHODS: 19 DMD patients (DMDG) (nine ambulatory and 10 non-ambulatory) were evaluated through motor function measure (MFM), 6-minute walk test (6MWT), respiratory muscle strength, cough peak flow, spirometry and volumetric capnography (VCap) tools. Control group that performed spirometry and VCap (CG1-n = 17) were different from those that performed the 6MWT (CG2-n = 8). RESULTS: The follow tools were assessed (p < 0.05) (i) MFM Ambulatory patients showed higher values than non-ambulatory patients; (ii) 6MWT DMDG walked a shorter distance and showed higher respiratory rate at rest and heart rate (HR) at rest than CG2; (iii) Spirometry DMDG and non-ambulatory patients had minor values achieved in spirometry when compared with CG1 and ambulatory patients, respectively; (iv) VCap DMDG when compared with CG1 showed (<11 years-old) lower values in VCap parameters; (>11 years-old) higher HR and lower slope 2. There was correlation between spirometry, mainly for zFEV1/FVC, and MFM. CONCLUSION: DMDG showed motor (MFM/6MWT) and respiratory (spirometry/VCap) deterioration when compared with CG. Non-ambulatory condition was associated with worse MFM and spirometry.