Snail-induced claudin-11 prompts collective migration for tumour progression.
Nat Cell Biol
; 21(2): 251-262, 2019 02.
Article
in En
| MEDLINE
| ID: mdl-30664792
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a pivotal mechanism for cancer dissemination. However, EMT-regulated individual cancer cell invasion is difficult to detect in clinical samples. Emerging evidence implies that EMT is correlated to collective cell migration and invasion with unknown mechanisms. We show that the EMT transcription factor Snail elicits collective migration in squamous cell carcinoma by inducing the expression of a tight junctional protein, claudin-11. Mechanistically, tyrosine-phosphorylated claudin-11 activates Src, which suppresses RhoA activity at intercellular junctions through p190RhoGAP, maintaining stable cell-cell contacts. In head and neck cancer patients, the Snail-claudin-11 axis prompts the formation of circulating tumour cell clusters, which correlate with tumour progression. Overexpression of snail correlates with increased claudin-11, and both are associated with a worse outcome. This finding extends the current understanding of EMT-mediated cellular migration via a non-individual type of movement to prompt cancer progression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Movement
/
Claudins
/
Snail Family Transcription Factors
/
Neoplasms
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2019
Document type:
Article
Affiliation country:
Taiwan