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Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma.
Dobson, Tara H W; Tao, Rong-Hua; Swaminathan, Jyothishmathi; Maegawa, Shinji; Shaik, Shavali; Bravo-Alegria, Javiera; Sharma, Ajay; Kennis, Bridget; Yang, Yanwen; Callegari, Keri; Haltom, Amanda R; Taylor, Pete; Kogiso, Mari; Qi, Lin; Khatua, Soumen; Goldman, Stewart; Lulla, Rishi R; Fangusaro, Jason; MacDonald, Tobey J; Li, Xiao-Nan; Hawkins, Cynthia; Rajaram, Veena; Gopalakrishnan, Vidya.
Affiliation
  • Dobson THW; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Tao RH; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Swaminathan J; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Maegawa S; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Shaik S; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Bravo-Alegria J; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Sharma A; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kennis B; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Yang Y; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Callegari K; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Haltom AR; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Taylor P; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kogiso M; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Qi L; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Khatua S; Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Goldman S; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
  • Lulla RR; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
  • Fangusaro J; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
  • MacDonald TJ; Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.
  • Li XN; Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
  • Hawkins C; Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
  • Rajaram V; Department of Pathology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Gopalakrishnan V; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Sci Signal ; 12(565)2019 01 22.
Article in En | MEDLINE | ID: mdl-30670636

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Chromatin / Cerebellar Neoplasms / Proto-Oncogene Proteins c-akt / Hedgehog Proteins / Patched-1 Receptor / Medulloblastoma Type of study: Prognostic_studies Limits: Adult / Animals / Child / Female / Humans / Infant / Male Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Chromatin / Cerebellar Neoplasms / Proto-Oncogene Proteins c-akt / Hedgehog Proteins / Patched-1 Receptor / Medulloblastoma Type of study: Prognostic_studies Limits: Adult / Animals / Child / Female / Humans / Infant / Male Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States