The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.
Science
; 363(6429): 880-884, 2019 02 22.
Article
in En
| MEDLINE
| ID: mdl-30679382
ABSTRACT
The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of ß-amyloid (Aß) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep deprivation (SD) increases Aß plaques. However, tau, not Aß, accumulation appears to drive AD neurodegeneration. We tested whether ISF/CSF tau and tau seeding and spreading were influenced by the sleep-wake cycle and SD. Mouse ISF tau was increased ~90% during normal wakefulness versus sleep and ~100% during SD. Human CSF tau also increased more than 50% during SD. In a tau seeding-and-spreading model, chronic SD increased tau pathology spreading. Chemogenetically driven wakefulness in mice also significantly increased both ISF Aß and tau. Thus, the sleep-wake cycle regulates ISF tau, and SD increases ISF and CSF tau as well as tau pathology spreading.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep
/
Sleep Deprivation
/
Wakefulness
/
Brain
/
Circadian Rhythm
/
Tau Proteins
/
Extracellular Fluid
Limits:
Animals
Language:
En
Journal:
Science
Year:
2019
Document type:
Article
Affiliation country:
United States