Controlling ionic conductivity through transprotein electropores in human aquaporin 4: a non-equilibrium molecular-dynamics study.
Phys Chem Chem Phys
; 21(6): 3339-3346, 2019 Feb 06.
Article
in En
| MEDLINE
| ID: mdl-30688325
ABSTRACT
Electroporation is a matter of intensive ongoing research interest, and a much-neglected topic in trans-membrane proteins, particularly in view of such promising potential applications in medicine and biotechnology. In particular, selected such novel and exciting applications are predicated on controlling ionic conductivity through electro-pores. Here, we scrutinise the mechanisms of ions' electric conductivity, by means of structural rearrangements, through quasi-stable electro-pores through human-AQP4 as a well-representative prototype of trans-membrane ionic conduction, achieving exquisite control over ionic permeability manipulated by the application of intense static electric fields.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aquaporin 4
/
Molecular Dynamics Simulation
Limits:
Humans
Language:
En
Journal:
Phys Chem Chem Phys
Journal subject:
BIOFISICA
/
QUIMICA
Year:
2019
Document type:
Article