Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years.
Environ Health Perspect
; 127(1): 17007, 2019 01.
Article
in En
| MEDLINE
| ID: mdl-30688513
ABSTRACT
BACKGROUND:
Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and child cognition.OBJECTIVES:
Our objective was to determine whether maternal urinary concentrations of OP pesticide metabolites are inversely associated with child nonverbal IQ at 6 y of age and to examine potential effect measure modification by the PON1 gene.METHODS:
Data came from 708 motherchild pairs participating in the Generation R Study. Maternal urine concentrations of six dialkylphosphates (DAPs), collected at [Formula see text], 1825, and [Formula see text] of gestation, were determined. Child nonverbal IQ was measured at 6 y of age using the Mosaics and Categories subtests from the Snijders-Oomen Nonverbal Intelligence Test-Revised. PON1 was determined in cord blood for 474 infants. Multiple linear regression models were fit to estimate the DAP-IQ associations and PON1 interactions.RESULTS:
Overall, associations between child nonverbal IQ and maternal DAP concentrations were small and imprecise, and these associations were inconsistent across urine sampling periods. Howover, for a 10-fold difference in total DAP concentration for the [Formula see text] of gestation samples, adjusted child nonverbal IQ was 3.9 points lower (95% CI [Formula see text], [Formula see text]). Heterogeneity in the DAPIQ association by PON1 gene allele status was not observed ([Formula see text]).CONCLUSIONS:
Consistent evidence of an association between higher maternal urinary DAP concentrations and lower child IQ scores at 6 y of age was not observed. There was some evidence for an inverse relation of child nonverbal IQ and late pregnancy urinary DAPs, but the estimated association was imprecise. https//doi.org/10.1289/EHP3024.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organophosphorus Compounds
/
Pesticides
/
Prenatal Exposure Delayed Effects
/
Intelligence
Type of study:
Prognostic_studies
Limits:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Country/Region as subject:
Europa
Language:
En
Journal:
Environ Health Perspect
Year:
2019
Document type:
Article
Affiliation country:
United States