Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats.

Gao, Dehong; Liu, Feng; Li, Zhipeng; Guan, Yifu

Gao, Dehong; Liu, Feng; Li, Zhipeng; Guan, Yifu.

Affiliation

Gao D; Department of Pathology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Liu F; Department ofï»¿ Nï»¿eurosurgery, Ankang Central Hospital, Ankang, China.
Li Z; HKBU Institute for Research and Continuing Education, Shenzhen, China; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address: zlybny@126.com.
Guan Y; HKBU Institute for Research and Continuing Education, Shenzhen, China. Electronic address: guanyifu200181@163.com.

Eur J Pharmacol ; 848: 49-54, 2019 Apr 05.

Article in En | MEDLINE | ID: mdl-30690005

Subject(s)

Acute Lung Injury/metabolism; Chalcones/therapeutic use; DNA-Binding Proteins/metabolism; Dextrans/toxicity; Heme Oxygenase-1/metabolism; Membrane Proteins/metabolism; NF-E2-Related Factor 2/metabolism; Acute Lung Injury/chemically induced; Acute Lung Injury/drug therapy; Animals; Chalcones/pharmacology; DNA-Binding Proteins/agonists; Dose-Response Relationship, Drug; Male; Membrane Proteins/agonists; NF-E2-Related Factor 2/agonists; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor alpha-Induced Protein 3

Key words

A20; Isobavachalcone; Lung injury; NF-κB; NRF2/HO-1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dextrans / Chalcones / DNA-Binding Proteins / Heme Oxygenase-1 / NF-E2-Related Factor 2 / Acute Lung Injury / Membrane Proteins Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2019 Document type: Article Affiliation country: China Country of publication: Netherlands

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