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Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
White, Gemma V; Edgar, Emma V; Holmes, Duncan S; Lewell, Xiao Qing; Liddle, John; Polyakova, Oxana; Smith, Kathrine J; Thorpe, James H; Walker, Ann L; Wang, Yichen; Young, Robert J; Hovnanian, Alain.
Affiliation
  • White GV; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Electronic address: gemma.v.white@gsk.com.
  • Edgar EV; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Holmes DS; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Lewell XQ; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Liddle J; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Polyakova O; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Smith KJ; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Thorpe JH; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Walker AL; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Wang Y; INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
  • Young RJ; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Hovnanian A; INSERM UMR1163 Laboratory of Genetic Skin Diseases, Imagine Institute and Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
Bioorg Med Chem Lett ; 29(6): 821-825, 2019 03 15.
Article in En | MEDLINE | ID: mdl-30691925
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamidines / Kallikreins / Serine Proteinase Inhibitors Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamidines / Kallikreins / Serine Proteinase Inhibitors Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom