Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [<sup>18</sup>F]FLT and [<sup>18</sup>F]ISO-1 PET/CT.

Elmi, Azadeh; Makvandi, Mehran; Weng, Chi-Chang; Hou, Catherine; Clark, Amy S; Mach, Robert H; Mankoff, David A

Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [¹⁸F]FLT and [¹⁸F]ISO-1 PET/CT.

Elmi, Azadeh; Makvandi, Mehran; Weng, Chi-Chang; Hou, Catherine; Clark, Amy S; Mach, Robert H; Mankoff, David A.

Affiliation

Elmi A; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Makvandi M; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Weng CC; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hou C; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Clark AS; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Mankoff DA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. david.mankoff@uphs.upenn.edu.

Clin Cancer Res ; 25(10): 3063-3073, 2019 05 15.

Article in En | MEDLINE | ID: mdl-30692100

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Breast Neoplasms/drug therapy; Cyclin-Dependent Kinase 4/antagonists & inhibitors; Cyclin-Dependent Kinase 6/antagonists & inhibitors; Animals; Breast Neoplasms/diagnostic imaging; Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Cell Proliferation/drug effects; Dideoxynucleosides; Estrogen Receptor Antagonists/administration & dosage; Female; Fluorine Radioisotopes; Fulvestrant/administration & dosage; Humans; Longitudinal Studies; MCF-7 Cells; Mice; Mice, SCID; Piperazines/administration & dosage; Positron Emission Tomography Computed Tomography/methods; Pyridines/administration & dosage; Radiopharmaceuticals; Random Allocation; Receptors, Estrogen/antagonists & inhibitors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 Type of study: Clinical_trials / Observational_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2019 Document type: Article

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