The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery.

Baer, Brandon; Veldhuizen, Edwin J A; Possmayer, Fred; Yamashita, Cory; Veldhuizen, Ruud

Baer, Brandon; Veldhuizen, Edwin J A; Possmayer, Fred; Yamashita, Cory; Veldhuizen, Ruud.

Affiliation

Baer B; Department of Physiology and Pharmacology, Western University, London, Ontario N6A 4V2, Canada.
Veldhuizen EJA; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Possmayer F; Department of Biochemistry, Western University, London, Ontario N6A 4V2, Canada.
Yamashita C; Department of Physiology and Pharmacology, Western University, London, Ontario N6A 4V2, Canada.
Veldhuizen R; Department of Medicine, Western University, London, Ontario N6A 4V2, Canada.

Discov Med ; 26(144): 207-218, 2018 11.

Article in En | MEDLINE | ID: mdl-30695680

Subject(s)

Drug Carriers/chemistry; Drug Delivery Systems/methods; Lung/drug effects; Pulmonary Surfactants/administration & dosage; Animals; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/pharmacokinetics; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/pharmacokinetics; Lung/metabolism; Lung/pathology; Macrophages/drug effects; Macrophages/physiology; Mice; Microbial Sensitivity Tests; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/growth & development; Pulmonary Surfactants/pharmacokinetics; RAW 264.7 Cells

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Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Surfactants / Drug Carriers / Drug Delivery Systems / Lung Type of study: Evaluation_studies Limits: Animals Language: En Journal: Discov Med Year: 2018 Document type: Article Affiliation country: Canada

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