Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene.

Nighot, Meghali; Rawat, Manmeet; Al-Sadi, Rana; Castillo, Eliseo F; Nighot, Prashant; Ma, Thomas Y

Nighot, Meghali; Rawat, Manmeet; Al-Sadi, Rana; Castillo, Eliseo F; Nighot, Prashant; Ma, Thomas Y.

Affiliation

Nighot M; Department of Medicine, Pennsylvania State University, School of Medicine, Hershey, Pennsylvania.
Rawat M; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Al-Sadi R; Department of Medicine, Pennsylvania State University, School of Medicine, Hershey, Pennsylvania.
Castillo EF; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Nighot P; Department of Medicine, Pennsylvania State University, School of Medicine, Hershey, Pennsylvania.
Ma TY; Department of Medicine, Pennsylvania State University, School of Medicine, Hershey, Pennsylvania; Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico. Electronic address: thomasma@pennstatehealth.psu.edu.

Am J Pathol ; 189(4): 797-812, 2019 04.

Article in En | MEDLINE | ID: mdl-30711488

Subject(s)

Calcium-Binding Proteins/metabolism; Cell Membrane Permeability/drug effects; I-kappa B Kinase/metabolism; Intestinal Mucosa/physiology; Lipopolysaccharides/pharmacology; MAP Kinase Kinase Kinases/metabolism; Myosin-Light-Chain Kinase/metabolism; Animals; Caco-2 Cells; Calcium-Binding Proteins/genetics; Female; Gene Expression Regulation/drug effects; Humans; I-kappa B Kinase/genetics; Intestinal Mucosa/drug effects; MAP Kinase Kinase Kinases/genetics; Male; Mice, Inbred C57BL; Myosin-Light-Chain Kinase/genetics; NF-kappa B/genetics; NF-kappa B/metabolism; Signal Transduction; Tight Junctions/drug effects; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myosin-Light-Chain Kinase / Calcium-Binding Proteins / Cell Membrane Permeability / Lipopolysaccharides / MAP Kinase Kinase Kinases / I-kappa B Kinase / Intestinal Mucosa Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Am J Pathol Year: 2019 Document type: Article Country of publication: United States

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