Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio rerio) following nitroreductase-mediated ß-cell ablation.

Rocker, Amanda; Howell, Julia; Voithofer, Gabrielle; Clark, Jessica Kennett

Rocker, Amanda; Howell, Julia; Voithofer, Gabrielle; Clark, Jessica Kennett.

Affiliation

Rocker A; Department of Biological Sciences, Salisbury University , Salisbury, Maryland.
Howell J; Department of Biological Sciences, Salisbury University , Salisbury, Maryland.
Voithofer G; Department of Biological Sciences, Salisbury University , Salisbury, Maryland.
Clark JK; Department of Biological Sciences, Salisbury University , Salisbury, Maryland.

Am J Physiol Regul Integr Comp Physiol ; 316(4): R395-R405, 2019 04 01.

Article in En | MEDLINE | ID: mdl-30726116

Subject(s)

Hyperglycemia/physiopathology; Insulin-Secreting Cells/metabolism; Nitroreductases/metabolism; Peripheral Nervous System/physiopathology; Animals; Animals, Genetically Modified; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Behavior, Animal/drug effects; Cell Count; Ganglia, Spinal/cytology; Ganglia, Spinal/metabolism; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Hyperglycemia/chemically induced; Hyperglycemia/psychology; Larva; Metronidazole/pharmacology; Motor Neurons/drug effects; Motor Neurons/metabolism; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nitroreductases/antagonists & inhibitors; Peripheral Nervous System/cytology; Schwann Cells/drug effects; Sensory Receptor Cells/metabolism; Zebrafish; Zebrafish Proteins

Key words

hyperglycemia; motor axons; perineurium; sensory neurons; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nitroreductases / Peripheral Nervous System / Insulin-Secreting Cells / Hyperglycemia Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: FISIOLOGIA Year: 2019 Document type: Article Country of publication: United States

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